• Patel Vijay
• Raval Anil

The aim of present investigation was formulation and development of Prazosin HCl Sustained Release Matrix Tablets. Study started from the preformulation study of the drug. Drug having good solubility in both dissolution mediums. The flow of API is low so directly compressible excipient used for tablet preparation. While studying IR spectrum, we can conclude that there is no interaction between drug and other excipients. Initially feasibility trials were taken using HPMC K4M and K100M. Tablets were found acceptable in physical parameters evaluation. During drug release evaluation amount of HPMC K4M increases the drug release for long period of time. In contrast less amount of HPMC K100M helps in drug release. So role of polymer concentration is very important in this formulation. Based on that F3 batch found satisfactory and considering for further factorial screening. 32 factorial design applied by taking HPMC K4M and PVP K-30 as independent factors. Factorial batch P1-P9 prepared by using direct compression method. Physical and chemical evaluation was done for all batches. PVP K-30 and HPMC K4M significantly impact on Drug release and hence the model found significant. Finally the optimized batch P12 taken based on Contour plot and evaluation done. Batch P12 load for stability for 1 month and found stable. Hence the batch P12 was optimized batch.

Prazosin HCl, Matrix Tablets, Sustained Release

"Formulation and Evaluation of Sustained Release Matrix Tablets of Prazosin Hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.565-574, April-2019, Available :http://www.jetir.org/papers/JETIR1904384.pdf

"Formulation and Evaluation of Sustained Release Matrix Tablets of Prazosin Hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp565-574, April-2019, Available at : http://www.jetir.org/papers/JETIR1904384.pdf