• Hiren Marvaniya
• Dr. Harsha U. Patel.

The thiazolopyrimidine derivatives was designed, synthesized and screened for inhibition of Dipeptidyl Peptidase IV (DPP IV). Methyl-5-amino-1,3-thiazole -4-carboxylate were reacted with urea to form scaffold, it was chlorination, alkaline hydrolysis, N-alkylationand amination to obtained final compounds. The final compounds were obtained Compound 1,2,3 having more DPP-IV inhibition activity. The present study on substituted thiazolopyrimidine derivatives shows good to moderate inhibitory potential of DPP IV enzyme.

[1,3]Thiazolo[5,4-D]Pyrimidine, Dipeptidyl Peptidase IV, Fluorescence intensity

"Synthesis and DPP-IV Inhibition Activity of [1,3]Thiazolo[5,4-D]Pyrimidine Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.86-90, April-2019, Available :http://www.jetir.org/papers/JETIR1904718.pdf

"Synthesis and DPP-IV Inhibition Activity of [1,3]Thiazolo[5,4-D]Pyrimidine Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp86-90, April-2019, Available at : http://www.jetir.org/papers/JETIR1904718.pdf