• B. Eswara Naik
• C. Narasimha Rao
• C. Narasimha Rao
• P. Venkateswarlu

A new precise, accurate, simple and sensitive spectrophotometric method has been developed for the determination of cabergoline (CAB) in pure and in pharmaceutical formulations. The present developed method is based on the formation of charge-transfer complex between the drug, CAB and 1-chloro-2,4-dinitrobenzene (CDNB) reagent, formed pale yellow color complex. The complex was showed maximum absorbance at 425 nm against blank. The limit of detection and quantitation were 0.1205 mg/ml and 0.4012 mg/ml respectively. The influence of commonly used exipients on the determination of CAB was studied. The linearity was observed between 5-30 µg/ml. The results of analysis were validated by recovery studies, accuracy, precision, LOD, LOQ, robustness and ruggedness, which indicated that the present method can be successfully applied for the determination of CAB in pure and in pharmaceutical formulations.

Spectrophotometric method, cabergoline, charge-transfer complex, CDNB.

"SPECTROPHOTOMETRIC DETERMINATION OF CABERGOLINE USING CDNB REAGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.188-194, April-2019, Available :http://www.jetir.org/papers/JETIR1904736.pdf

"SPECTROPHOTOMETRIC DETERMINATION OF CABERGOLINE USING CDNB REAGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp188-194, April-2019, Available at : http://www.jetir.org/papers/JETIR1904736.pdf