• ASHIDA S
• Dr. PRABHAKUMARI C

In India Saraca asoca (Family: Fabaceae; Subfamily: Caesalpinaceae), commonly known as ‘Sita Ashoka’ has been widely used in traditional medicine for many ailments such leucorrhoea, bleeding hemorrhoids, dysfunctional uterine bleeding etc. The aerial parts of the tree are chiefly used in medicines and it has been reported to contain chemicals such as glycoside, flavonoids, tannins, saponins, alkanes, esters and primary alcohols. The aim of this study was to investigate the mutagenicity and antimutagenicity of leaf extracts of S. asoca by the Salmonella microsome assay (Ames test) using Salmonella typhimurium tester strains TA100 without (S9) metabolization, by the preincubation method. S. asoca leaves were found to be strongly antimutagenic against sodium azide. Considering the excellent antimutagenic activities showed by the leaf extracts of S. asoca, we conclude that it is a good source for chemo preventive agents. But further study has to be done to characterize the phyto chemical or combination of phytochemicals that impart chemo preventive properties to S. asoca leaf extracts.

Mutagenicity, medicinal plants, Saraca asoca, chemopreventive

"CHEMOPREVENTIVE PROPERTIES OF LEAF EXTRACTS OF SARACA ASOCA IN SALMONELLA TYPHYMURIUM STRAIN TA-100", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.362-367, April-2019, Available :http://www.jetir.org/papers/JETIR1904D49.pdf

"CHEMOPREVENTIVE PROPERTIES OF LEAF EXTRACTS OF SARACA ASOCA IN SALMONELLA TYPHYMURIUM STRAIN TA-100", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp362-367, April-2019, Available at : http://www.jetir.org/papers/JETIR1904D49.pdf