• Sreevidya.Puvvala
• Divya.Velpula
• Lakshmi kalpana

ABSTRACT: Metoprolol succinate (MS) gastro retentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Floating tablets were used to increase the gastric residence time of dosage forms. Such dosage forms are better because they reduce the inter-subject variability in absorption and lower probability of dose dumping by reducing frequency of dosing. The objective of this study was to develop floating tablets of Metoprolol succinate using natural polymer having desirable properties in order to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and there by improved bioavailability. In this work Natural gums (Okra gum, Hibiscus rosa sinensis leaves mucilage, gum karaya) are used, which where not used till date in the formulation of Metoprolol succinate floating matrix tablets. Sodium bicarbonate was used as gas generating agent. Floating tablets of Metoprolol succinate were prepared by Wet granul;ation technique using Okra gum, Hibiscus rosa-sinensis and Gum karaya which showed controlled release of the drug for a prolonged period of time.The natural polymers used showed drug release retarding nature, and the release retarding nature was in order of Gum karaya>Hibiscus rosa-sinensis>Okra gum.Compared to other gums used, Gum karaya has high viscosity value and good drug release retarding capacity.There is a similarity between the viscosities of the polymers and their release retarding profiles.The powder folw properties such as Bulk density,Tapped density ,Angle of repose, carr’s Index Hausner ratio were measured.The concentration of sodium bicarbonate influences the lag time. The FT-IR studies were performed which clearly indicates that there are no drug and polymer interactions .The prepared Metoprolol succinate floating tablets complies with the specifications of the Pharmacopoeial standards.

Keywords: Metoprolol succinate ,Gum karaya, Okra gum, Hibiscus rosa sinensis, Floating tablets

"DESIGN AND DEVELOPMENT OF FLOATING TABLETS OF METOPROLOL SUCCINATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.12-37, April-2019, Available :http://www.jetir.org/papers/JETIR1904J02.pdf

"DESIGN AND DEVELOPMENT OF FLOATING TABLETS OF METOPROLOL SUCCINATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp12-37, April-2019, Available at : http://www.jetir.org/papers/JETIR1904J02.pdf