• SREEVIDYA PUVVALA
• divya velpula
• srilakshmi nallapaty

ABSTRACT: Spherical crystallization is a technique by which crystallization and agglomeration can be carried out simultaneously in one step and which has been successfully utilized for improvement of flowability and compactability of crystalline drugs. It is a simple process and inexpensive enough for scaling up to a commercial level, which reduces time and cost by involving faster operation, less machinery, and fewer personnel, with great advances in tabletting technology, especially the introduction of a number of directly compressible excipients. Irbesartan is slightly soluble in alcohol and methylenechloride and practically insoluble in water. Irbesartan is clinically used alone or combined with other antihypertensive agents to treat hypertension. Irbesartan is a fluffy material, with relatively low bulk and tapped densities. These properties make it difficult to formulate a large amount of the drug into a small tablet. Irbesartan is a nonpeptide tetrazole derivative and an angiotensin II antagonist that selectively blocks the binding of angiotensin II to the AT 1 receptor. Spherical agglomerates prepared by the quasi emulsion solvent diffusion method showed an improvement in the solubility, dissolution rate, compactability, wettability, flow ability and bioavailability. These spherical agglomerates also showed excellent physico-chemical characters as compared with plain drug which indicates that the spherical agglomerates can suitable for directly compressible tablet process.

KEYWORDS: IRBESARTAN, PVP-K90, CMC, MC, HPMC

"ENHANCING THE FLOW PROPERTIES AND DISSOLUTION RATE OF IRBESARTAN BY USING SPHERICAL CRYSTALLIZATION TECHNIQUE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.248-273, April-2019, Available :http://www.jetir.org/papers/JETIR1904J34.pdf

"ENHANCING THE FLOW PROPERTIES AND DISSOLUTION RATE OF IRBESARTAN BY USING SPHERICAL CRYSTALLIZATION TECHNIQUE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp248-273, April-2019, Available at : http://www.jetir.org/papers/JETIR1904J34.pdf