• Durgavati Yadav
• Vivek Pandey
• Shivani Srivastava
• Mohan Kumar
• Yamini Bhusan Tripathi

Aim of the study: Excessive free radicals generated by chronic hyperglycaemia contribute to the development of diabetic nephropathy (DN). Here, the effect of Pueraria tuberosa in alloxan induced DN has been explored. Methodology: DN was induced by administering alloxan (120 mg/kg in chilled normal saline, ip) in albino rats (CF strain, both sexes, 7-8 weeks old) at regular intervals to maintain higher blood glucose. Tubers of Pueraria tuberosa (Bidarikand, PT) has been taken for the study as it is reported in the treatment of kidney disorders. Renal damage was assessed by renal functional tests, histopathology and oxidative stress. Antioxidant parameters were measured; serum urea and creatinine levels were assessed in four groups with PTME treated group (40 mg/100g BW for seven days and 20 mg/100g BW for 14 days to diabetic rats of alloxan treated and two groups each with PTME to normal treated rats), diabetic control and normal group. Results: PTME showed significant protection (P<0.05) by decreasing urea and creatinine as compared to the diabetic control. It improves kidney physiology by increasing its decreased antioxidant level. Histopathology reports supported the experimental findings. Conclusion: These results suggested that PT might act as beneficial against renal impairment through antioxidant mechanisms.

"Methanolic extract of Pueraria tuberosa Linn ameliorates renal injury and oxidative stress in rats with alloxan-induced diabetes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.557-574, April-2019, Available :http://www.jetir.org/papers/JETIR1904J74.pdf

"Methanolic extract of Pueraria tuberosa Linn ameliorates renal injury and oxidative stress in rats with alloxan-induced diabetes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp557-574, April-2019, Available at : http://www.jetir.org/papers/JETIR1904J74.pdf