• M. Hema Mani
• A. Jayachitra

Objective: To determine the anti-inflammatory activity of ethanolic extract of Plumbago zeylanica Linn leaves (EEPZ), and its possible mechanism of action. Methods: Wistar albino female rats (150-200 g) were used in this study. The animals were housed in poly propylene cages in the standard environmental conditions of 20-250C temperature, 12 h light: 12 h dark cycle, and fed with standard rodent pellet diet and water ad libitum. The groups were divided into 5 groups (n=6/group) and assigned as positive control, negative control, and standard and two different test dose groups of P. zeylanica. Paw edema induced by phlogistic agent of 0.05 mL of carrageenan (suspended in 1% carboxymethyl cellulose) into the left hind paw in all groups except negative control group. Granuloma induced by cotton pellets (10±1 mg) were implanted into groin region of each rat. The groups were divided into 4 groups (n=6/group) and assigned as possitive control, two different test dose groups of P. zeylanica and standard. Results: Oral administration of EEPZ shown a significant (p<0.05) dose-dependent protection against carrageenan-induced paw edema. At 1st hr, P. zeylanica shown an inhibition effect of edema in the different doses of 100 mg/kg and 150 mg/kg were found and got the significant result (p<.001). Conclusion: Thus, the present study revealed that the EEPZ offered significant protection against inflammation.

Anti-inflammatory, EEPZ, Plumbago Zeylanica, paw edema.

"ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF PLUMBAGO ZEYLANICA LINN LEAVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.365-368, April-2019, Available :http://www.jetir.org/papers/JETIR1904L53.pdf

"ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF PLUMBAGO ZEYLANICA LINN LEAVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp365-368, April-2019, Available at : http://www.jetir.org/papers/JETIR1904L53.pdf