• Dr.Srinivasarao.Tumati
• Dr.srinivasarao.R
• Dr.B.C.K Reddy
• Dr.R.Venkanna

Pantoprazole belongs to benzimidazole group. It is a proton pump inhibitor, used for the treatment of gastric and duodenum ulcers. It undergoes degradation in acid medium of the stomach, can be coated with enteric coating polymer that will safely deliver the drug in the small intestine. A simple dissolution test method for Pantoprazole pellets dosage forms has been proposed and HPLC analytical method was developed for the measurement of Pantoprazole pellets dosage forms with Detector .The chromatographic system consists of 4.0mm x 12.5CM, 5µ Packing L7 column, an gradient mobile phase of 340 ml of Acetonitrile+660ml phosphate buffer. The flow rate is 1ml /minute and elute is tested at 280nm.The pantoprazole was eluted 4.569min with no interfering peak from additives used for preparation dosage forms. The method was linear over the range of 10-125µg/ml pantoprazole. The dissolution test was conducted in 6.8 phosphate buffer, 900ml with paddle RPM at 100.Dissolution was found to be NTL 75% in 45 minutes. The proposed method was applied successfully for the measurement of Pantoprozole content in pellets dosage forms

Dissolution tester, HPLC, Pantoprazole Pellets dosage forms, RPM, Mobile phase

"Dissolution test Method and HPLC analysis for Pantoprazole Pellets dosage forms.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.535-541, April-2019, Available :http://www.jetir.org/papers/JETIR1904M80.pdf

"Dissolution test Method and HPLC analysis for Pantoprazole Pellets dosage forms.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp535-541, April-2019, Available at : http://www.jetir.org/papers/JETIR1904M80.pdf