• Niranjan Sutar
• Dr Yogendra singh

Platycladus orientalis (L) Franco (PO) which is also known as Thuja has been used traditionally to treat various disease as diabetes, fever, epilepsy, pain, inflammation including peptic ulcer disease in Indian and chinese folk medicine, but its scientific efficacy in many disorder has not been validated. The present study was therefore carried out to evaluate the anti-ulcer activity of ethanol leaf extract of P. orientalis in rats. The effect of plant extracts on gastric ulcer in rats in ethanol-induced models was studied using dose (100, 200mg/kg). Omeprazole (50 mg/kg) were used as the standard drugs. On the ethanol-induced models, outcome measures were volume and pH of gastric fluid, total acidity, ulcer score, percent inhibition of ulcer score, ulcer index as well as percent inhibition of ulcer index. Data were analyzed using one-way analysis of variance and P<0.05 was considered as statistically significant. PO significantly (P<0.001) reduced gastric ulcer index by 62.12%, in ethanol-induced ulcer models by ethanolic extract at the 200 mg/kg dose, which is comparable to the standard drugs. Various extract of PO possesses both dose-dependent and time-dependent anti-ulcer effect in the animal model. The oral median lethal dose (LD50) is estimated to be higher than 2000 mg/kg for the crude alcoholic extract, and secondary metabolites such as terpenoids, flavonoids, alkaloid and saponins were present. The findings of this study confirmed that PO has anti-ulcer pharmacologic activity due to one or more of the secondary metabolites present in it. Therefore, this study validates its anti-ulcer use in Chinese and Indian folk medicine for use in gastric ulcer.

Anti-ulcer activity, In vivo, Platycladus orientalis, Rat, Traditional

"Evaluation of Anti-Ulcer Potential of the Leaf Extracts of Platycladus orientalis (L) Franco (Cupressaceae,) in Ethanol-induced ulcer in Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.1925-1936, April-2019, Available :http://www.jetir.org/papers/JETIR1904S81.pdf

"Evaluation of Anti-Ulcer Potential of the Leaf Extracts of Platycladus orientalis (L) Franco (Cupressaceae,) in Ethanol-induced ulcer in Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp1925-1936, April-2019, Available at : http://www.jetir.org/papers/JETIR1904S81.pdf