• Vaibhav A. Mane
• Sheetal V. Palande
• Dr. Deelip K. Swamy

The new Schiff base ligand (L1H) (E)-N-(5,6-dimethoxypyrimidin-4-yl)-4-((2-hydroxy-5-nitrobenzylidee)amino) benzene sulphonamide (DMPHNAB) was synthesized from 4-amino-N-(5,6-dimethoxypyrimidin-4-yl) benzene sulphonamide and 2-hydroxy-5-nitrobenzaldehyde and the geometry of Schiff base was characterized and determined by proton nuclear magnetic resonance (1H-NMR), mass, Fourier transform infrared (FT-IR), and ultraviolet-visible (UV-Vis) spectroscopy. By the reaction of metal ions with as-prepared Schiff base, Schiff base complexes of Ni (II), Co (II), Cu (IV), Zn (II), and Mn(II) were prepared. The results showed that synthesized complexes offered 1:2 metal-ligand ratios. Furthermore, the Schiff complexes of Ni (II), Zn (II), Cu (II), and Mn (II) are octahedral. Moreover, the Schiff base and its metal complexes have been verified in vitro against S. Aurius, E. coli, Candida albicans, and A. Niger in order to assess their antibacterial potential. The results suggest that biological activity increases in the reaction of complexation.

Schiff Bases, metal complexes, Biocidal Activity, spectral analysis.

"SYNTHESIS AND ANTIMICROBIAL ACTIVITY STUDY OF NOVEL SCHIFF BASE LIGAND (E)-N-(5,6-DIMETHOXYPYRIMIDIN-4-YL)-4-((2-HYDROXY-5-NITROBENZYLIDEE)AMINO) BENZENE SULPHONAMIDE AND THEIR TRANSITION METAL COMPLEXES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.40-48, April-2019, Available :http://www.jetir.org/papers/JETIR1904T06.pdf

"SYNTHESIS AND ANTIMICROBIAL ACTIVITY STUDY OF NOVEL SCHIFF BASE LIGAND (E)-N-(5,6-DIMETHOXYPYRIMIDIN-4-YL)-4-((2-HYDROXY-5-NITROBENZYLIDEE)AMINO) BENZENE SULPHONAMIDE AND THEIR TRANSITION METAL COMPLEXES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp40-48, April-2019, Available at : http://www.jetir.org/papers/JETIR1904T06.pdf