• Kamalesh Digambar Kulkarni
• Dr. Neelu Jain

The design strategies employed for the synthesis of nitrogen-containing anticancer agents. The results of different studies describe the N-heterocyclic ring system is a core structure in many synthetic compounds exhibiting a broad range of biological activities. Benzimidazole, benzothiazole, indole, acridine, oxadiazole, imidazole, isoxazole, pyrazole, triazoles, quinolines and quinazolines including others drugs containing pyridazine, pyridine and pyrimidines are covered. The following studies of these compounds suggested that these compounds showed their antitumor activities through multiple mechanisms including inhibiting protein kinase (CDK, MK-2, PLK1, kinesin-like protein Eg5 and IKK), topoisomerase I and II, microtubule inhibition, and many others. Our concise representation exploits the design and anticancer potency of these compounds. The direct comparison of anticancer activities with the standard enables a systematic analysis of the structure activity relationship among the series

Nitrogen-Containing, Anticancer Activities, Heterocyclic Moieties.

"DESIGN STRATEGIES OF NITROGEN-CONTAINING HETEROCYCLIC MOIETIES FOR THEIR ANTICANCER ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.1043-1051, April-2019, Available :http://www.jetir.org/papers/JETIR1904U34.pdf

"DESIGN STRATEGIES OF NITROGEN-CONTAINING HETEROCYCLIC MOIETIES FOR THEIR ANTICANCER ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp1043-1051, April-2019, Available at : http://www.jetir.org/papers/JETIR1904U34.pdf