• Anil Binjhade
• Vinoy Kumar Shrivastava

In the present study, the para-nonylphenol (p-NP) induced, oxidative stress in the kidney of male Mus musculus and co-administration of vitamin-C can ameliorate any possible oxidative stress. For which 20 male Mus musculus (P) were divided in to four groups of 5 each. Group I served as control received normal diet and water adlibitum, group II exposed with (250 mg/kg bw) para-nonylphenol orally and Group III exposed with para-nonylphenol (250mg/kg bw) along with co-administered with Vitamin-C (10ppm) and While, Group IV supplemented with Vitamin-C alone (10ppm) for 30 and 60 days, and histopathological, enzymological i.e. GOT, GPT, ACP and ALP and biochemical parameter i.e. cholesterol and creatinine levels were carried out. In histological observations, noted that para-nonylphenol induced hypertrophied, degenerative and pyknotic change in renal cells after 30 and 60 days. While, the animals supplemented with vitamin-C alongwith para-nonylphenol up to 30 and 60 days showed recoveries in renal cells. In connection to this, the enzyme activities i.e. GOT, GPT, ACP and ALP and biochemical parameter i.e. cholesterol and creatinine levels were significantly elevated by para-nonylphenol in 30 and 60 days treatement, However, there change were become lowered towards normalcy when vitamin-C supplemented alongwith para-nonylphenol.

para-Nonylphenol, Vitamin-C, enzymes, Mus musculus, histopathology, oxidative damage.

" “Ameliorative role of Vitamin-C against para-nonylphenol induced toxicity in kidney of male Mus musculus (P)”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.467-478, April-2019, Available :http://www.jetir.org/papers/JETIR1904V17.pdf

" “Ameliorative role of Vitamin-C against para-nonylphenol induced toxicity in kidney of male Mus musculus (P)”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp467-478, April-2019, Available at : http://www.jetir.org/papers/JETIR1904V17.pdf