• K. Saleem
• Dr. T. Nargis Begum
• Dr. M.H. Muhammad Ilyas

In this study protective activity of ethanol extract of Azima tetracantha leaves (ATL) was investigated using carbon tetrachloride (CCl4)-intoxicated rat liver as the experimental model. In the present study, the elevated activity of ALT, AST, ACP, ALP, GGT, LDH, and content of Bilirubin were observed in the animals treated with CCl4. Administration of Azima tetracantha leaf extract at the dose of 100, 200 and 400mg per kg body weight shows dose dependent decrease in the activity of liver marker enzymes. Among the various doses, 400mg/kgbw showed the significant effect was observed when compared with other doses (100 and 200mg/kgbw). The ATL extract exhibited significant hepatoprotection against CCl4 induced liver injury in rats through antioxidant potential and free radical scavenging activities.

Carbon tetrachloride, Azima tetracantha leaves, Liver marker enzymes

"EFFECT OF Azima tetracantha ON LIVER MARKERS OF CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.481-485, May-2019, Available :http://www.jetir.org/papers/JETIR1905169.pdf

"EFFECT OF Azima tetracantha ON LIVER MARKERS OF CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp481-485, May-2019, Available at : http://www.jetir.org/papers/JETIR1905169.pdf