• Hetal K. Panchal

Abstract: Artemisinin based derivatives are currently in vast use as an antimalarial agents. In spite of this we need more novel antimalarial agents, as development of resistance against artemisinin compounds is already reported in at Thailand –Myanmar boreder and Combodia in Plasmodia. In this study we took help of in-silico approach to find out possible antimalarial components present in tulsi and mamejavo plants using Swissdock and ZINC database, as they are traditionally used in malaria treatment. Enzymes namely dihydroxy pteroate synthetase (dhps), dihydroxyfolate reductase (dhfr) (2BL9) and thymidylate kinase (2YOF) either from Plasmodium vivax or Plasmodium falciparum were docked against 11 components, as they are key enzymes in metabolism of Plasmodium. Among all best results against all 4 proteins were given by laminoribiose, but it violates Lipinski’s rule of five. Next to that best results were given by catechin and swertiamarin for 2BL9 and 2YOF. No promising results were found for any dhps. In silico drug docking may prove a better approach for any drug designing before going through any in vivo or in vitro analysis. It may really speed up the process of finding new drug agents and even cost cutting, which are necessities of recent time.

Plasmodium, dhps, dhfr, Thymidylate kinase, Swissdock

"DOCKING OF FEW PLASMODIUM ENZYMES USING SWISSDOCK", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.645-651, May-2019, Available :http://www.jetir.org/papers/JETIR1905196.pdf

"DOCKING OF FEW PLASMODIUM ENZYMES USING SWISSDOCK", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp645-651, May-2019, Available at : http://www.jetir.org/papers/JETIR1905196.pdf