• K.Vanaja
• Dr.R.Sivasankar
• Dr. K. Chennaiah,

The roots and the rhizomes of Nardostachys jatamansi, are used to treat Muscle weakness, epilepsy, hysteria, mental and neurological disorders. Nicotine is highly addictive, It is one of the most commonly abused drugs, Several studies in humans and animal models provide evidence that nicotine does indeed result in muscle wasting. Age matched rats were be divided into 4 groups of six in each group and treated as follows: group i) Normal Control (NC) (Control rats received 0.9% saline) ; ii) Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months ); iii) Nardostachys Jatamansiextract treated (NJEt) (50mg/kg body weight) via orogastric tube for a period of 2 months); IV) Nicotine + Nardostachys Jatamansi extract treated (Nt+NJEt), rats were received the nicotine at a dose as mentioned in Group II through subcutaneous injection and N. Jatamansi extract as mentioned in Group III via orogastric tube for a period of 2 months. The animals were sacrificed after 24 hrs after the last treatment by cervical dislocation. Isolated the skeletal muscle tissue and measured the activity levels of Superoxidedismutase (SOD), Catalase (CAT), Glutathione (GSH) and Glutathioneperoxidase (GPx). The decrease was observed in nicotine treated rats and increase was observed in NJEt rats over the control. . In the combination treatment (Nt+NJEt) up regulation was observed. In the present investigation, the antioxidant properties of Nardostachys jatamansi, are studied effectively.

Nardostachys jatamansi Extract, Nicotine, Skeletal Muscle tissue, SOD, CAT, GSH, GPx, and Male albino rat, Aging.

"Antioxidant activity of Nardostachys jatamansi aligned with Nicotine induced stress on Skeletal muscle tissue of male Albino rat with reference to the Aging", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.145-163, May-2019, Available :http://www.jetir.org/papers/JETIR1905F22.pdf

"Antioxidant activity of Nardostachys jatamansi aligned with Nicotine induced stress on Skeletal muscle tissue of male Albino rat with reference to the Aging", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp145-163, May-2019, Available at : http://www.jetir.org/papers/JETIR1905F22.pdf