• Gulafsha Khan
• Mrs.Jyoti Mantri

Antibiotic resistance is rising to dangerously high levels in all parts of the world, making alternative antimicrobials essential. The high prevalence of oral candidiasis and the restricted number of antifungal agents available to control it, justifies the development of new therapies for use in daily clinical practice.The medical impact of C.albicans typically depends on its ability to form virulent factors and biofilms, which attach to surfaces, such as tissues and implanted medical devices and also dentures.These biofilms serve as drug-resistant reservoirs of cells that can multiply and cause denture stomatitis and subsequent bloodstream infections. Chlorhexidine gluconate is a widely used potent oral antiseptic that has side effects such as toxicity, burning sensation, teeth staining, disagreeable smell, and taste. This study compares activity of apple cider vinegar withChlorhexidine gluconate, in combating denture stomatitis caused by Candida albicans.Macrodilution technique was used to determine the minimum inhibitory concentration(MIC) and minimum fungicidal concentration (MFC) of apple cider vinegar and chlorhexidine. Apple cider vinegar showed MIC/MFC of 2500µg/ml whereas chlorhexidine showed MIC/MFC of 7.8µg/ml.The effect of ACV(test),CHX(standard) and distilled water(control) on inhibition of biofilm formation by Candida albicans using acrylic resin was studied by comparing the number of colony-forming units (cfu/ml) of the adhered microorganisms.The mean value of cfu/ml in the control group (distilled water), standard group (Chlorhexidine)and ACV(test) were 3×105,8×102and 5×104respectively.This study further aims to assess the effect of ACV on the virulence factors, germ tube of C.albicans and phagocytic activity of monocytes that are the key effectors of innate immunity using flow cytometer.

Apple Cider Vinegar (ACV), Denture stomatitis, C.albicans, Root canal failure.

"Anticandida and immunomodulating activity of Apple cider vinegar; its use in treating denture stomatitis and as a root canal irrigate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.600-610, May-2019, Available :http://www.jetir.org/papers/JETIR1905H96.pdf

"Anticandida and immunomodulating activity of Apple cider vinegar; its use in treating denture stomatitis and as a root canal irrigate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp600-610, May-2019, Available at : http://www.jetir.org/papers/JETIR1905H96.pdf