• R.Subarani
• P.Metilda

ABSTRACT: The Schiff base ligand was prepared by condensation of pyrrole-2-carboxaldehyde with Alanine. Cu(II), Co(II), Mn(II), Zn(II) and Ni(II) complexes of above ligand was synthesised as well. The synthesised ligand and complexes have characterized by IR, UV, Powder XRD, SEM and EDAX. The antimicrobial activity of the synthesized ligand and its complexes have been tested for their antibacterial activity against bacterial species Basillus subtilis, Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Pseudomonaos aeruginosa, Staphylococcus aureus and fungal species Candida albicans and Aspergillus niger. The result found that the metal complexes were more active than the ligand. Antioxidant activites of ligand and its metal complexes have also been studied. The Antioxidant activity indicate that the complexes show higher activity than the ligand.The DNA cleavage activityof the ligand and its metal complexeshave been studied.The result found that the Zn(II) complex effectively cleave pUC 18 DNA.

Pyrrole-2-carboxaldehyde, Alanine, metal complexes, XRD, SEM.

"Biological applications of Pyrrole-2-carboxaldehyde derived Schiff base ligand and their transition metal complexes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.53-62, May-2019, Available :http://www.jetir.org/papers/JETIR1905J10.pdf

"Biological applications of Pyrrole-2-carboxaldehyde derived Schiff base ligand and their transition metal complexes", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp53-62, May-2019, Available at : http://www.jetir.org/papers/JETIR1905J10.pdf