• V Alekhya
• Adi Lakshmi Challa
• Puja Chalimadugu
• Bandi Padmaja
• Usha Manduri

In traditional system of medicine, couroupita guianensis Linn leaves were used for various ailments including diabetes, inflammation, depression, hypertension, malaria, antibiotic, skin diseases etc. To investigate the anti-arthritic activity of the above leaves, the present study was carried out on Fruend’s adjuvant induced arthritis in rats.The present study states that the effect of the ethanolic extract of Fruend’s complete adjuvant induced rheumatoid arthritis in rat paw edema, body weight changes and alterations haematological and biochemical parameters in both developing and developed phases of arthritis. Histopathology of proximal interphalangeal joints and radiology of hind legs were studied.In FCA induced arthritic rats, there was significant increase in rat paw volume and decrease in body weight increment, there ascouroupita guianensistreated groups showed significant reduction in paw volume and normal gain in body weight. The altered haematological parameters and serum parameters in the arthritic rats were significantly brought backto near normal by the couroupita guianensis leaf treatment at the dose of 200mg/kg in both developing phases of arthritis. Further the histopathological and radiological studies revealed the anti-arthritic activity of couroupita guianensis leaf by indicating fewer abnormalities in these groups when compared to the arthritic control group.In conclusion, couroupita guianensis leaf extract at the specified dose level of 200mg/kg, showed reduction in rat paw edema volume and it could significantly normalize the haematological and biochemical abnormalities in adjuvant induced arthritic rats in both developing and developed phases of FCA induced arthritis. Further the histopathological and radiological studies confirmed the antiarthritic activity of couroupita guianensis.

Couroupita guianensis, Histopathological studies, Radiological studies

"EFFECT OF ETHANOLIC EXTRACT OF COUROUPITA GUIANENSIS LEAF ON FRUEND’SCOMPLETE ADJUVANT INDUCED RHEUMATOID ARTHRITIS IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.510-521, May-2019, Available :http://www.jetir.org/papers/JETIR1905J76.pdf

"EFFECT OF ETHANOLIC EXTRACT OF COUROUPITA GUIANENSIS LEAF ON FRUEND’SCOMPLETE ADJUVANT INDUCED RHEUMATOID ARTHRITIS IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp510-521, May-2019, Available at : http://www.jetir.org/papers/JETIR1905J76.pdf