• Nagarathna PKM
• Ikenna E.E
• Edna U.M
• K Ramesh
• GITIMA DEKA

Liver fibrosis is a dynamic pathological condition which can be slowed down in its initial phases. Without proper clinical management of fibrosis, progressive liver damage may lead to cirrhosis and ultimately to liver failure or primary liver cancer, which are irreversible conditions. Therefore, in order to cure fibrotic damage to liver, its early stages should be the centre of attention. The pathological determining factor of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue. The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)- initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signalling pathways In the progression of chronic liver entry to fibrosis, all hepatic cells undergo specific changes. The hepatocytes are injured and they undergo apoptosis. The sinusoidal endothelial cells undergo a loss of fenestrae that is termed acapillarization of the sinusoids. The resident macrophage in the liver, the Kupffer cell, activates and produces a variety of chemokine’s and cytokines. Lymphocytes infiltrate the injured liver and contribute to the inflammation.. This article reviews potent natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action.

Extracellular matrix proteins; Fibrosis; Hepatocytes; Herbal medicine; Liver; Natural products; Regulators

"Potent Natural Product Used In The Management of Liver Fibrosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.277-282, May-2019, Available :http://www.jetir.org/papers/JETIR1905K38.pdf

"Potent Natural Product Used In The Management of Liver Fibrosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp277-282, May-2019, Available at : http://www.jetir.org/papers/JETIR1905K38.pdf