• Hamsa D
• Sanya.K.K

Medicinal plants besides therapeutic agents are also a big source of information for a wide variety of chemical constituents which could be developed as drugs with precise selectivity and in line with this the present study was focused on determining the anti-cancer potential of Pisonia alba alcoholic extracts. The extracts were found to have alkaloids, glycosides and tannins as the major secondary metabolites which exhibited significant antioxidant activity when determined by ABTS assay. The extracts show negligible anti-bacterial activity upon agar well diffusion assay. MTT assay on breast cancer cell lines MDA MB has shown a dose dependent inhibition of cell proliferation with an LC 50 value of 15.2ug/ml. Apoptosis was confirmed by fluorescent microscopy and the anti-metastatic activity was determined by clonogenic assay. RT PCR analysis has shown activation of MAPK and ERK which shares significant role in anti-proliferation activity of Pisonia which needs to be explored for utilising its anti-cancer activity.

Anticancer, Poisonia alba, Triple negative Breast cancer, Phytochemicals and antioxidants

"ANTI-CANCER ACTIVITY OF Pisonia alba IN TRIPLE NEGATIVE BREAST CANCER CELLS (MDA-MB-231)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.461-468, May-2019, Available :http://www.jetir.org/papers/JETIR1905Q65.pdf

"ANTI-CANCER ACTIVITY OF Pisonia alba IN TRIPLE NEGATIVE BREAST CANCER CELLS (MDA-MB-231)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp461-468, May-2019, Available at : http://www.jetir.org/papers/JETIR1905Q65.pdf