• JUHI DUBEY
• DR NARENDRA LARIYA

Diclofenac Sodium an NSAID, used for the treatment of rheumatoid arthritis and osteoarthritis. Tizanidine is a Clonidine congener.It inhibits polysynaptic reflexes; reduces muscle tone and frequency of muscle spasms without reducing muscle strength. An improved Diclofenac Sodium-Tizanidine Hydrochloride formulation with a high degree of permeation could be useful in treatment of locally inflamed skin, inflammatory and painful states of supporting structures of the body.The trandermal Patches were formulated using varying ratio of hyrophillic polymers, penetration enhancers and plasticizers Dimethyl sulfoxide and Polyethylene glycol 400 dissolved in methanol-water by solvent casting method. The Physiochemical properties of patches were evaluated. Combination strategy of drugs and permeation enhancers showed convincing results with significant improvement in the transportation of Diclofenac Sodium-Tizanidine Hydrochloride carried out by permeation studies using Franz diffusion cell on rat abdominal skin. Tween 80 (5%w/w) and span 80 (5%w/w) were identified as key enhancers that could improve the transport of Diclofenac Sodium-Tizanidine Hydrochloride across the skin. The drug release kinetics followed zero order kinetics and data from koresmeyer-peppas model indicates that the release mechanism follow fickian diffusion. The percent of drug permeated in 12 h was found to be maximum 99.8± 0.01 and 98.98± 0.01 % from formulations FA2 and FA8 respectively. Hence the transdermal patch would prove to be a promising formulation.

Key Words-Transdermal Patch, Physiochemical Properties, Diclofenac Sodium, Tizanidine Hydrocloride,Franz Diffusion cell

"Formulation and Evaluation of Transdermal patches of Diclofenac Sodium and Tizanidine Hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.474-485, May-2019, Available :http://www.jetir.org/papers/JETIR1905Q67.pdf

"Formulation and Evaluation of Transdermal patches of Diclofenac Sodium and Tizanidine Hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp474-485, May-2019, Available at : http://www.jetir.org/papers/JETIR1905Q67.pdf