• B Kavitha
• CH. VINUTHA KUMARI
• B. RAMESH

The nucleophilic substitution reaction of phenacyl bromide with benzimidazole has been studied conductometrically in methanol medium in the temperature range 303-318K. The reaction is observed to be first order with respect to both [bezimidazole] and [phenacyl bromide]. The reaction is overall second order. Substituent effect on rate of the reaction suggests that electron withdrawing groups (p-NO2, p-Cl, m-NO2) enhance the rate of the reaction compared to the unsubstituted compound, while the electron donating group (p-OCH3) decrease the rate of the reaction compared to unsubstituted compound. The substituted (p-OCH3, p-NO2 and p-Cl) and the unsubstituted compound form a linear free energy relationship. From the intersection of lines in the Hammett and Arrhenius plots, the isokinetic temperature is discussed.

phenacyl bromide, bezimidazole, isokinetic temperature, LFER

"Effect of Substituent and Nucleophile in the Phenacylation of Benzimidazole ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1066-1072, May-2019, Available :http://www.jetir.org/papers/JETIR1905S58.pdf

"Effect of Substituent and Nucleophile in the Phenacylation of Benzimidazole ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1066-1072, May-2019, Available at : http://www.jetir.org/papers/JETIR1905S58.pdf