• Dr. Jisha S P
• Dr. K N Rajasekharan

Several sydnone derivatives show a broad range of physiological activities, including antimicrobial, anti-inflammatory, analgesic and antipyretic properties Hence, chemists have been enthusiastically pursuing the synthesis of such derivatives. Besides, thiazoles and their derivatives exhibit various biological activities such as antimicrobial, anti-inflammatory, antiviral, antituberculosis and cytotoxic activities, among others. Consequent to these reports, the present study seeks to synthesize a series of novel thiazole derivatives that contain the sydnonyl moiety, with the aim of obtaining new biologically active compounds. In view of the continued interest in the development of simpler and more convenient synthetic routes for preparing heterocyclic systems, an efficient and useful method is reported herein to synthesize some new sydnone-substituted thiazoles.

1-Aryl-3-(N,N’-diarylamidino)thioureas, Bromoacetylsydnones, Dendrodoine , Sydnone, Thiazole

"Synthesis, Characterization, Antibacterial and Antifungal Activities of Novel 2, 4-bis(arylamino)-5-(3-arylsydnon-4-oyl)thiazoles and 2-(N,N-disubstituted amino)-5-(3-arylsydnon-4-oyl)-4-phenylthiazoles ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1368-1378, May 2019, Available :http://www.jetir.org/papers/JETIR1905T05.pdf

"Synthesis, Characterization, Antibacterial and Antifungal Activities of Novel 2, 4-bis(arylamino)-5-(3-arylsydnon-4-oyl)thiazoles and 2-(N,N-disubstituted amino)-5-(3-arylsydnon-4-oyl)-4-phenylthiazoles ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1368-1378, May 2019, Available at : http://www.jetir.org/papers/JETIR1905T05.pdf