• Pramod Mourya
• Rohit Singhal
• Neetesh K Jain1

To control blood sugar levels, traditional healers have used this plant as remedies. The aim of this study is to investigate hypolipidemic and hypoglycemic effect of the whole plant of Alternanthera Pungens Kunth against Alloxan induces hyperglycemia in rats. An injection of Alloxan monohydrate 150 mg/kg (i.p.) was used to induce hyperglycemia. After 72 hrs, the rats were selected for the investigation whose blood glucose level (BGL) was above 150 mg/dl. The two different doses of aqueous, and ethanolic extracts (200 mg/kg and 400 mg/kg b.w.) were observed for antidiabetic effect. BGL was monitored and compared with metformin (250 mg/kg). Both extracts showed significant (P<0.05) antihyperglycemic activity after doses of both the extracts have been given orally in a dose-dependent manner in alloxan-induced diabetic rats. After 21 days of treatment with ethanolic extract at dose of 400 mg/kg, the BGL decrease from 268.34±4.82 to 104.68±4.28 mg/dl, the reduction in BGL with aqueous extract at dose 400 mg/kg from 269.46±7.09 to 114.38 mg. The ethanolic and aqueous extract resulted in reduction of the blood glucose level, it is primarily because of the flavonoids constituents, present in it. So, this current study supports the traditional use of Alternanthera Pungens Kunth in the treatment of the diabetes and contributes as evidence for their use in traditional medicine.

Key Words: Antihyperglycemia, Blood Glucose Level (BGL), Diabetes mellitus, Metformin, Alternanthera Pungens Kunth etc.

"EVALUATION OF ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF ALTERNANTHERA PUNGENS KUNTH ON ALLOXAN INDUCED DIABETIC RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1513-1520, May-2019, Available :http://www.jetir.org/papers/JETIR1905T23.pdf

"EVALUATION OF ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF ALTERNANTHERA PUNGENS KUNTH ON ALLOXAN INDUCED DIABETIC RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1513-1520, May-2019, Available at : http://www.jetir.org/papers/JETIR1905T23.pdf