• Swati Tiwari
• Neetesh Kumar Jain2

The current study is focused on the in-vivo therapeutic effect of hepatoprotective activity of aqueous extract of triphala loaded solid lipid nanoparticle (SLNs) in Tetracycline induced hepatotoxicity in mice. Albino mice of either sex (35-40 gm) were selected and treated preclinically for 14 days and designated into various treatment groups including Normal, Toxic, standard and formulation treatment groups.The biochemical markers like (AST, ALT, ALP and serum bilirubin) were evaluated by using Erba diagnostic kit. The in vivo antioxidant activity was determined by estimating the tissue levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO). The triphala/ bioactive & their formulation (100 and 50mg/kg) produced significant effect by decreasing the activity or level of AST, ALT, ALP and serum bilirubin and while it significantly increased the levels of tissue GSH, SOD and CAT in a dose-dependent manner. The in-vivo histopathology of liver was also carried out.Overall, the current research significantly concluded that aqueous extract of triphala/bioactive & their formulation possesses hepatoprotective activity against tetracycline induced hepatotoxicity.

Keywords: Silymarin; Triphala; Solid lipid nanoparticle; Antioxidant activity, Hepatoprotective activity, tetracycline

"HIGHER THERAPEUTIC BENEFITS OF AQUEOUS EXTRACT OF TRIPHALA LOADED SOLID LIPID NANOPARTICLE IN TETRACYCLINE INDUCED HEPATOTOXICITY IN ANIMAL MODEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1521-1537, May-2019, Available :http://www.jetir.org/papers/JETIR1905T24.pdf

"HIGHER THERAPEUTIC BENEFITS OF AQUEOUS EXTRACT OF TRIPHALA LOADED SOLID LIPID NANOPARTICLE IN TETRACYCLINE INDUCED HEPATOTOXICITY IN ANIMAL MODEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1521-1537, May-2019, Available at : http://www.jetir.org/papers/JETIR1905T24.pdf