• Deval J. Modi
• Dr. Divyesh H. Shastri
• Dr. Pragna K. Shelat

Improvement of solubility and dissolution rate of Modafinil, the Fluidized hot melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by the use of a low melting point binder which is added to the other components of the powder. The effect of the binder properties and concentration on agglomerate growth mechanisms studied using FHMG technique. Modafinil drug and Optimized concentrations of Low-melting point co-polymers of PEG 6000, PEG 4000, Gelucire 50/13, Gelucire 44/14, Poloxamer 188 and Poloxamer 407 in different ratios (i.e., 1:1, 1:2, 1:3 and 1:4) as meltable binder’s mixture top sprayed dropwise over lactose as diluent which loaded into fluid bed chamber to prepare granules of Modafinil and evaluated for Micromeritical properties, DSC, XRD etc. The tablets prepared from the granules while other excipients added was evaluated for drug dissolution rate. The granules were found to have excellent flow properties indicated by mean diameter D50:122µm, Carr’s index 13.89 ± 0.01% and 98.87 ± 1.03% drug content uniformity. XRD data exhibited partial loss of crystallinity indicated by significantly less intensity of the modafinil peak in sample than pure modafinil. Absence of modafinil endothermic peak at higher proportions of meltable binder reported by DSC data exhibited amorphous form of modafinil leads to complete solubilization and thus faster dissolution rate of modafinil. Drug release from tablet was fast found 98.52 ± 1.53% within 30 minutes. The Fluidized hot melt granulation technique is an easy and fast method to improve the dissolution rate of poorly water-soluble drug such as a modafinil, using new hydrophilic Meltable binder.

Fluidized Hot Melt Granulation, Fluidized bed granulation, Meltable Binder, Top Spray, Modafinil

"TO EXPLORE POTENTIAL OF FLUIDIZED HOT MELT GRANULATION TECHNIQUE TO IMPROVE MICROMERITICS PROPERTIES AND DISSOLUTION RATE OF MODAFINIL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1799-1807, May-2019, Available :http://www.jetir.org/papers/JETIR1905T57.pdf

"TO EXPLORE POTENTIAL OF FLUIDIZED HOT MELT GRANULATION TECHNIQUE TO IMPROVE MICROMERITICS PROPERTIES AND DISSOLUTION RATE OF MODAFINIL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1799-1807, May-2019, Available at : http://www.jetir.org/papers/JETIR1905T57.pdf