• Shailendra Kumar
• Sinu Bharti

The present study was designed to evaluate the LPO (Lipid peroxidation) in sodium arsenite treated mice model and arsenic exposed women of Bihar. Female Swiss albino mice (n= 35) were selected as experimental animals. Arsenic treated mice were grouped into 5 groups. Normal women (n= 25) and arsenic exposed ovarian cancer patients (n= 50) from arsenic affected districts of Bihar were selected as the human model and blood samples were collected with their prior consent of the subjects. LPO levels were performed according to the protocol. ap < 0.05 for control mice group versus Sodium arsenite treated mice Group A; bp < 0.01 for control mice group versus Sodium arsenite treated mice Groups B, C, D and E. It was found that with an increase in the dose duration of sodium arsenite after successive 1, 2, 3, 4 and 5 months respectively, the LPO level increased significantly in all arsenic-treated groups as compared to the control group of mice. For the comparison of two-groups, i.e., normal women with ovarian cancer patients form arsenic hit districts, the level of significance for 't' test was p ≤ 0.05. The LPO levels were significantly (p < 0.05 for Bhagalpur district and for rest of the districts p < 0.01) higher in ovarian cancer patients form all arsenic hit districts as compared to the normal women from those districts. The conclusions showed that the mechanism of arsenic induced oxidative stress in ovarian tissues. Hence there was relationship among ovarian carcinoma, LPO and arsenic belt of Bihar.

Arsenic, Swiss albino mice, Ovary, LPO, Ovarian cancer

"Comparative Study of LPO Levels in the Ovarian Tissue of Arsenic Induced Female Mice and its Correlation with Ovarian Cancer Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1984-1988, May-2019, Available :http://www.jetir.org/papers/JETIR1905T84.pdf

"Comparative Study of LPO Levels in the Ovarian Tissue of Arsenic Induced Female Mice and its Correlation with Ovarian Cancer Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1984-1988, May-2019, Available at : http://www.jetir.org/papers/JETIR1905T84.pdf