• Ashish Suttee
• Chaudhary Samrita Hardev

Squalamine, a natural cationic steroid isolated and extracted from different species of dogfish shark (Squalus acanthias) and later identified in the circulating white blood cells of Sea lamprey (Petromyzon marinus). This compound is used as a novel approach in the treatment of various tumors by targeting angiogenesis-associated tumors, which plays a crucial role in the formation of metastati. The chemical representation of squalamine is 7,24 dihydroxylated 24-sulphate steroid conjugated with spermidine at position C-3, which possesses strong anti-angiogenic properties and causes tumour proliferation, invasion and migration disruption. Its mechanism of action includes, when it binds to the cell membrane, inhibits the sodium hydrogen exchanger membrane and also functions as a calmodulin chaperone. Various theories of the mechanism of action of squalamine have been covered in this review paper, highlighting the role of squalamine in the treatment of various types of tumors and retinal diseases, despite the advancement of cancer therapy. Comparative analysis of squalamine with other anti-angiogenic steroids is covered despite of lacking glucocorticoids and mineralocortiocoids showing its anti-angiogenic properties without a much side effects because it is a natural derived product and when combined with chemotherapy agents, its anti-angiogenic properties have been improved in many clinical and pre-clinical studies.

Squalamine, Ovarian Cancer, Lung Cancer

"SQUALAMINE: PLAYS A MAJOR ROLE IN THE TREATMENT OF TUMOR AND RETINAL DISEASES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.2575-2610, May-2019, Available :http://www.jetir.org/papers/JETIR1905U64.pdf

"SQUALAMINE: PLAYS A MAJOR ROLE IN THE TREATMENT OF TUMOR AND RETINAL DISEASES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp2575-2610, May-2019, Available at : http://www.jetir.org/papers/JETIR1905U64.pdf