• Mohammad Zia Rasekh
• Pranav Kumar Prabhakar

Thyroid disease such as hypothyroidism and hyperthyroidism are the most prevalent hormonal disorders in these years. The thyroid disease can be diagnosed in the form of clinical and subclinical form. Thyroid disease is described as “The alteration in serum thyroid stimulating hormone level with normal or altered thyroid hormones”. Thyroid hormones involve in the synthesis, mobilization and degradation of lipids. The degradation effects of thyroid hormones are more predominant than the synthesis effects in lipids. The association between thyroid disorders and lipids has been known for 70 years ago in the term of hypercholesterolemia. Because the thyroid hormones involve in the regulation of some key enzymes activity in lipids transport. Hydroxy methyl glutaryl coenzyme redcutase involve in the synthesis of cholesterol. Presence of free intracellular cholesterol inhibits HMG CoA reducatase thus; the cholesterol synthesis decreases. But the thyroid hormones induce the HMG-CoA reductase and the enzyme directly increases the synthesis of cholesterol. Many observational studies approved that the level of Total cholesterol, Triglycerides, very low-density lipoprotein and low density lipoprotein increase above the normal range and the high density lipoprotein decrease from the normal range in overt hypothyroidism. Thyroid stimulating hormones have deleterious effect on serum lipids thus; elevation in TSH values directly might change lipids values. The studies suggested that the TSH has adipogenesis and lipolysis effects. As well as, TSH increase the activity of HMG-CoA reductase thus; increase the cholesterol level in hepatocytes. The studies suggested that the prevalence of hyperthyroidism is decreased in hyperlipidemic patients. In a study reported that the prevalence of hyperthyroidism is 3 out of 248 hyperlipidemic patients.

Thyroid stimulating hormone, Thyroid hormones, Thyroid dysfunctions, Serum Lipids

"ASSOCIATION OF THYROID FUNCTION ABNORMALATIES AND SERUM LIPIDS - A REVIEW ARTICLE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.3067-3081, May-2019, Available :http://www.jetir.org/papers/JETIR1905V25.pdf

"ASSOCIATION OF THYROID FUNCTION ABNORMALATIES AND SERUM LIPIDS - A REVIEW ARTICLE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp3067-3081, May-2019, Available at : http://www.jetir.org/papers/JETIR1905V25.pdf