• SUVODEEP GHOSAL
• Dr. SUMAN KHATRY

Lung cancer is the leading cause of cancer death worldwide. Histologically, 80% of lung cancers are classified as non-small cell lung cancer (NSCLC), and the remaining 20% as small-cell lung cancer (SCLC). Lung carcinoma is the result of molecular changes in the cell, resulting in the deregulation of pathways controlling normal cellular growth, differentiation, and apoptosis. This review summarizes some of the most recent findings about the role of cell-cycle proteins in lung cancer pathogenesis and progression. The mammalian cell cycle is important in controlling normal cell proliferation and the development of various diseases. Cell cycle checkpoints are well regulated by both activators and inhibitors to avoid cell growth disorder and cancerogenesis. Cyclin dependent kinase 20 (CDK20) and p21Cip1/Waf1 are widely recognized as key regulators of cell cycle checkpoints controlling cell proliferation/growth and involving in developing multiple cancers. Emerging evidence demonstrates that these two cell cycle regulators also play an essential role in promoting cell survival independent of the cell cycle, particularly in those cells with a limited capability of proliferation, such as cardiomyocytes. These findings bring new insights into understanding cytoprotection in these tissues. Here, we summarize the new progress of the studies on these two molecules in regulating cell cycle/growth, and their new roles in cell survival by inhibiting various cell death mechanisms. We also outline their potential implications in cancerogenesis and protection in heart diseases. This information renews the knowledge in molecular natures and cellular functions of these regulators, leading to a better understanding of the pathogenesis of the associated diseases and the discovery of new therapeutic strategies.

Cell cycle; CDK20; p21Cip1/Waf1; cancer; cardiovascular disease

"A STUDY OF CELL-CYCLE SURVIVAL WITH REGULATORS IN DUAL FUNCTIONS OF LUNGS CANCER ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.3212-3220, April-2019, Available :http://www.jetir.org/papers/JETIR1905V41.pdf

"A STUDY OF CELL-CYCLE SURVIVAL WITH REGULATORS IN DUAL FUNCTIONS OF LUNGS CANCER ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp3212-3220, April-2019, Available at : http://www.jetir.org/papers/JETIR1905V41.pdf