• R. Sapthagiri
• L. Ilavarasan
• A. Ravi
• K. Mohanraj
• S. Selvaraj

A series of phenyl substituted pyrazole derivatives demonstrate a wide range of biological and Pharmacological activities. They are found to be as effective as local anesthetics, antibacterial, anti-malarial, anti-protozoal, anti-tubercular, anticancer, cardiovascular, antiulcer and antifungal agents. These different properties of chalcones have prompted us to synthesize them in order to study their medicinal and biological activities. In this study, a series of substituted pyrazole linked chalcones were synthesized by 4-hydroxybenzaldehyde, 4-nitroacetophenone, 4-chloroacetophenone, hydrazine hydrate and PEG-600. The synthesized compounds were characterized by FT-IR, UV-Visible, and 1H NMR techniques. The purity of the synthesized compounds was monitored by TLC and tested for their antimicrobial activity by Minimum Inhibitory Concentration (MIC) method against two different microorganisms (Staphylococcus aureus and Escherichia coli. The antimicrobial activities of the synthesized compounds of pyrazole derivatives are more active than the corresponding chalcones.

Substituted chalcone derivatives, Pyrazole, Antimicrobial activity, MIC.

"DESIGN AND FACILE SYNTHESIS OF PHENYL SUBSTITUTED PYRAZOLE DERIVATIVES AND ITS BIOLOGICAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.131-138, June-2019, Available :http://www.jetir.org/papers/JETIR1906022.pdf

"DESIGN AND FACILE SYNTHESIS OF PHENYL SUBSTITUTED PYRAZOLE DERIVATIVES AND ITS BIOLOGICAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp131-138, June-2019, Available at : http://www.jetir.org/papers/JETIR1906022.pdf