• Pramod K P
• Dr. K Ramesh
• Rashmi Mathews
• Dr. Beny baby
• Rajarajan S

The objective of the research work was to formulate and evaluate transdermal patches of Enalapril maleate, an antihypertensive drug, for controlled release. The transdermal formulation was prepared by solvent casting method by incorporation of various polymers like Gum rosin, PVP in different proportions. PEG 400 and Glycerin were used as Plasticizer and DMSO Permeation enhancer. The prepared patches were evaluated for various physiochemical properties like Folding endurance, Moisture Uptake, Moisture content, Weight variation ,Film thickness, Drug content and In-vitro drug release studies. FT-IR and DSC studies revealed that there was no interaction between the drug and polymers used in the study. The drug release studies were performed for 16 h at 37°C ± 1°C.The optimized formulation F9 was found to be clear, with pH 7.4 and the drug content was found to be more than 85 % in ethanol and showed release of drug up to 89.23 % in 16 h. It showed no significant changes on stability studies when stored at 40 ± 2°C/ 75%RH ± 5% for two months according to ICH guidelines. The drug release of optimized formulation was found to follow Zero order. The n-value of Korsmeyer–Peppas plot was found 1.0013 indicating that most formulations may have followed non-Fickian diffusion mechanism, The R2 value for F9 was found to be 0.9742, 0.8211. 0.9037, 0.921, Zero order, First order, Higuchi model, Peppas model respectively. So, it follows the Zero order of drug release.

Transdermal patch; Enalapril maleate; Controlled release; Gum Rosin; Polyvinyl Pyrrolidone; Permeation enhancer

"Formulation and Evaluation of Transdermal Patches of an Antihypertensive Drug for Controlled Release", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.444-452, June-2019, Available :http://www.jetir.org/papers/JETIR1906210.pdf

"Formulation and Evaluation of Transdermal Patches of an Antihypertensive Drug for Controlled Release", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp444-452, June-2019, Available at : http://www.jetir.org/papers/JETIR1906210.pdf