• Akshay Kumar
• Dr. Beny Baby
• Rajarajan S

The objective of the study was to develop buccal films of Enalapril Maleate for the treatment of hypertension with minimal side effects, controlled release and patient compliance. The buccal films are orally administered medicament that deliver drug for local or systemic effects at a predetermined and controlled rate. Buccal drug delivery system avoids hepatic first pass metabolism and gastrointestinal irritation. The Enalapril maleate buccal films were prepared by solvent casting method by incorporation of polymers like gum rosin, ethyl cellulose. . The Enalapril maleate buccal films were evaluated for swelling index, folding endurance, film thickness and in-vitro drug release. The drug release study was performed by using phosphate buffer 7.4 pH. The optimized formulation (F9) provides controlled release of drug up to 87.73 % in 16 h. The optimized formula showed no significant changes on stability studies when stored at 40ºC/75% RH for two month according to ICH guidelines The r2 values of zero order of F9 formulation have shown higher values which indicates the drug release is directly proportional to time which means release of Enalapril maleate follows zero order

Enalapril Maleate; Gum rosin; Ethyl cellulose; DMSO; Glycerol; buccal films; Solvent casting

"Development of a Polymer Film Dosage Form for Buccal Administration In the treatment of Hypertension", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.453-462, June-2019, Available :http://www.jetir.org/papers/JETIR1906211.pdf

"Development of a Polymer Film Dosage Form for Buccal Administration In the treatment of Hypertension", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp453-462, June-2019, Available at : http://www.jetir.org/papers/JETIR1906211.pdf