• Dr.K. Bhavyasri
• B.Bhairavi
• Dr.D.Rambabu

A rapid method for the determination of paracetamol in human blood serum using first derivative absorption spectroscopy is described. It involves no sample treatment, extraction or derivatization procedures ,other than a standard deproteinizing technique with trichloroacetic acid. The percentage of relative recovery and coefficient of variation of accuracy and precision were within acceptable limits. The method proved in simple, cost effective, and sensitive foe estimation of Paracetamolin human plasma. This results can be applied to both therapeutic and toxic levels of Paracetamol.

Paracetamol, human plasma, method development, validation, bio analytical procedure.

"METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PARACETAMOL IN HUMAN PLASMA BY UV SPECTROPHOTOMETRY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.572-577, June-2019, Available :http://www.jetir.org/papers/JETIR1906227.pdf

"METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PARACETAMOL IN HUMAN PLASMA BY UV SPECTROPHOTOMETRY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp572-577, June-2019, Available at : http://www.jetir.org/papers/JETIR1906227.pdf