• Narsu Kumari K
• kalyani V
• Pavan Kumar D
• Gayathri Devi K
• Prudhvi Chand P

The present study was undertaken to develop an efficient, rapid, reproducible and sensitive RP- HPLC method for the simultaneous estimation of cephalexin in tablet dosage forms. The developed method was validated as per ICH guidelines. The HPLC method was developed using waters C18 column (250mm×4.6mm; 5µ id) and flow rate 1.0ml /min. Detection was carried out at by absorption at 240nm and injection volume is 20µl. The mobile phase used was methanol and 0.1M sodium acetate buffer in ratio of 75:25 v/v. The calibration curve was linear over the range of 5-30µg/ml. The proposed method was validated according to ICH guidelines. The method was found to be simple, economical, suitable, precise, accurate & robust method for quantitative analysis of cephalexin in tablet dosage forms.

Cephalexin, tablet dosage form, RP-HPLC method, validation

"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CEPHALEXIN BY RP-HPLC METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.696-699, June-2019, Available :http://www.jetir.org/papers/JETIR1906244.pdf

"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CEPHALEXIN BY RP-HPLC METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp696-699, June-2019, Available at : http://www.jetir.org/papers/JETIR1906244.pdf