• Seema A. Gosavi
• Dattatray H. Nandal
• Sarita S Pawar

Novel isoxazoline derivatives were synthesized by condensation of varyingly substituted acetophenone with aldehyde in presence of alcoholic sodium hydroxide to get intermediate chalcones, which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazoline derivatives. The latter were refluxed separately with Isonicotinic acid hydrazide and Sulphanilamide in presence of formaldehyde for 6-10 h to afford corresponding Mannich bases. The structures of synthesized compounds were established on the basis of melting point, TLC, IR, 1H NMR and HRMS. The derivatives were evaluated for the radical scavenging activity compared to the standard Ascorbic acid. The results of antioxidant study show that some of the derivatives posses mild to moderate activity as compared to standard.

Chalcone, Isoxazoline, Mannich bases, Antioxidant activity.

"Synthesis, Characterization and Antioxidant DPPH Scavenging Assay of Some Novel Mannich Bases of Isoxazoline Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.380-387, June-2019, Available :http://www.jetir.org/papers/JETIR1906345.pdf

"Synthesis, Characterization and Antioxidant DPPH Scavenging Assay of Some Novel Mannich Bases of Isoxazoline Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp380-387, June-2019, Available at : http://www.jetir.org/papers/JETIR1906345.pdf