• ZaberUnnisa
• Sruthi.K
• Syeda Advia Sanobar
• M.Sumakanth

Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at an increasing rate. All the mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivity and reduced reaction times will make it a technique of interest to synthetic chemists Many mechanochemical reactions of organic compounds take place at low milling energy that is not sufficient to break primary bonds, but the gentle mechanical grinding can influence the relative position of macromolecules, leading to the formation of unique co-crystals and compounds. In inorganic systems, unusual products form due to forced mixing and the high defect density generated by intense milling. . This article provides an overview of mechanochemical reaction examples by direct comparison to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution

Mechanochemistry, Green chemistry synthesis, mechanochemical reactions, milling energy, organic compounds.

"REVIEW ON MECHANO-CHEMICAL APPROACHES IN DRUG DESIGN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.583-599, June-2019, Available :http://www.jetir.org/papers/JETIR1906374.pdf

"REVIEW ON MECHANO-CHEMICAL APPROACHES IN DRUG DESIGN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp583-599, June-2019, Available at : http://www.jetir.org/papers/JETIR1906374.pdf