• SANDHYARANI ANIL NIKAM
• SANDHYARANI ANIL NIKAM
• SACHIN VINAYAK TEMBHURNE
• SWATI .U. KOLHE

The objective of this study to evaluate the sub-acute toxicity of the ethanolic extract of sesbania grandiflora flower [family- Fabaceae] in wistar rat. Herbal medicine is the source for the search of many novel therapeutic compounds in developing countries. Before used as medicine, drugs from plant origin must be ensured safe. The study is aimed at evaluating the possible toxicity in 28-day sub-acute oral toxicity of ethanolic extract Sesbania grandiflora flower extract) in male and female Wistar rats. The 28-day sub-acute toxicity study was conducted to detect the no-observed adverse effect level . In this study, a total of 48 rats were divided into the control, low dose (200 mg/kg), medium dose (500 mg/kg) and high dose (1000 mg/kg) groups. The extract was administered daily from day 28. At the end of the study, the animals were sacrificed and assessed for the effect extract of Sesbania Grandiflora flower extract on body weight and relative organ weights and hematological, biochemical and histopathological parameters. The hematological and serum biochemical parameters for the assessment of kidney and liver injuries were carried out. Results of hematological and serum biochemistry results showed no changes in the control and treated groups. In the histopathology, evaluation of kidney tissues in all treated groups showed no significant (p > 0.05) lesions.

sub-acute oral toxicity, Sesbania grandiflora, biochemical analysis, hematological parameters, histopathology.

"EVALUATION OF SUBACUTE ORAL TOXICITY STUDY INDUCED BY ETHANOLIC EXTRACT OF SESBANIA GRANDIFLORA FLOWER EXTRACT IN EXPERIMENTAL RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.764-782, June-2019, Available :http://www.jetir.org/papers/JETIR1906403.pdf

"EVALUATION OF SUBACUTE ORAL TOXICITY STUDY INDUCED BY ETHANOLIC EXTRACT OF SESBANIA GRANDIFLORA FLOWER EXTRACT IN EXPERIMENTAL RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp764-782, June-2019, Available at : http://www.jetir.org/papers/JETIR1906403.pdf