• SHIRISH KUMAR KODADI
• SWETHA KOVURI

,Abstract : Understanding the charge transfer process between bioactive molecules and inorganic or organic molecules is significant as this interaction can be used to interpret bioactive molecule–receptor interactions. A comprehensive spectrophotometric study has been performed to explore the complexation chemistry of the Crizotinib (CZT) with 2,6-dibromoquinone-4-chloroimide (DBQ) as π - acceptor. The molecular structure, spectroscopic characteristics and the interactive modes have been deduced from UV–Vis and FT-IR spectra. The binding ratio of complexation has been determined to be 1:1 for DBQ with CZT. Benesi–Hildebrand method was applied to estimate the spectroscopic and physical data. The association constant (K), extinction coefficient (εmax), ionization potential (IP), energy of the charge transfer complex (ECT), resonance energy (RN), dissociation energy (W) and standard Gibbs energy ( G0) have been computed. Based upon the obtained spectroscopic data, the plausible CT mechanism between CZT and DBQ was proposed.

Spectrophotometry, Spectroscopy, CZT, DBQ, Charge transfer complexation, Computational study.

"SYNTHESIS, SPECTROPHOTOMETRIC, THERMODYNAMIC AND SPECTROSCOPIC STUDIES OF CT COMPLEXES OF NOVEL CRIZOTINIB WITH 2,6-DIBROMOQUINONE-4-CHLOROIMIDE AS Π - ACCEPTOR", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.874-887, June-2019, Available :http://www.jetir.org/papers/JETIR1906420.pdf

"SYNTHESIS, SPECTROPHOTOMETRIC, THERMODYNAMIC AND SPECTROSCOPIC STUDIES OF CT COMPLEXES OF NOVEL CRIZOTINIB WITH 2,6-DIBROMOQUINONE-4-CHLOROIMIDE AS Π - ACCEPTOR", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp874-887, June-2019, Available at : http://www.jetir.org/papers/JETIR1906420.pdf