• R.SUBARANI
• P.METILDA

ABSTRACT: The Schiff base ligand was prepared by condensation of pyrrole-2-carboxaldehyde with Glutamic acid. Cu(II), Co(II), Mn(II), Zn(II) and Ni(II) complexes of above ligand was synthesised as well. The synthesised ligand and complexes have characterized by IR, UV, 1HNMR, EPR, Powder XRD, SEM and EDAX. The antimicrobial activity of the synthesized ligand and its complexes have been tested for their antibacterial activity against bacterial species Basillus subtilis, Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Pseudomonaos aeruginosa, Staphylococcus aureus and fungal species Candida albicans and Aspergillus niger. The result found that the metal complexes were more active than the ligand. Larvicidal activites of ligand and its metal complexes have also been studied. The DNA cleavage activity of the ligand and its metal complexes have been studied.The result found that the Cu(II) complex effectively cleave pUC 18 DNA.

Pyrrole-2-carboxaldehyde, Glutamic acid, XRD, SEM.

"Synthesis, Characterization, Antimicrobial Activity and DNA cleavage of Transition Metal Complexes of Pyrrole-2-Carboxaldehyde with Glutamic acid", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.322-332, June-2019, Available :http://www.jetir.org/papers/JETIR1906776.pdf

"Synthesis, Characterization, Antimicrobial Activity and DNA cleavage of Transition Metal Complexes of Pyrrole-2-Carboxaldehyde with Glutamic acid", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp322-332, June-2019, Available at : http://www.jetir.org/papers/JETIR1906776.pdf