• Mayuri Shelar
• Swati Kolhe
• Sachin Tembhurne

Objective-5-fluorouracil-induced (5-FU), an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity. The study objective was to investigate the protective effects of Buchanania lanzan on 5-FU-induced hepatotoxicity. Material and Methods- Male Wistar rats were assigned to seven groups. Weighing 220–250 g, were included in the study. The animals were housed under adequate moisture and light conditions, at a suitable room temperature, and were provided with sufficient water and food until the day of the experiment. The control group received distilled water for 21 days. The second group of animals injected only with 5-FU (20 mg/kg i.p) on day 17 to 21. Third, fourth group of animals administered with extract of Buchanania lanzan (200 and 400 mg/kg p.o.) and injected with 5-FU on day 17 to 21. Fifth and Sixth group of animals only injected with extract of Buchanania lanzan (200 and 400mg/kg p.o.) and seventh group of animals injected with standard Silymarin for 21 days respectively and injected with 5-FU (20 mg/kg i.p) on day 17 to 21. On day 22, the rats were decapitated, and blood and hepatic tissues were taken. Buchanania lanzan was observed to have a protective effect on 5-FU induced Liver toxicity. Results of histopathological examination also revealed multifocal moderate hepatocellular vacuolation (macro vesicular) in 5-FU treated rats while prior treatment with Buchnania lanzan for 21 days showed focal mild hepatocellular vacuolation in liver. Conclusion-In this study it was determined that the Buchaniana lanzan have protective effects on 5-FU-induced liver toxicity.

Buchanania lanzan spreng seed, Aqueous ethanolic extract, 5-Flurouracil, Silymarin, Hepatoprotective, Histopathology.

"CHEMOPROTECTIVE EFFECT OF BUCHANANIA LANZAN SEED EXTRACT ON TOXICITY OF 5- FLUROURACIL INDUCED HEPATOTOXICITY IN RATS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.127-131, June-2019, Available :http://www.jetir.org/papers/JETIR1906799.pdf

"CHEMOPROTECTIVE EFFECT OF BUCHANANIA LANZAN SEED EXTRACT ON TOXICITY OF 5- FLUROURACIL INDUCED HEPATOTOXICITY IN RATS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp127-131, June-2019, Available at : http://www.jetir.org/papers/JETIR1906799.pdf