• Anjali Gusain

A simple, unique and dependable UV-VIS spectrophotometric method used to be as soon as developed for the estimation of Olanzapine in bulk and pharmaceutical dosage forms. Water: Hydrochloric acid (9:1) was chosen as the solvent system. The λmax was discovered to be 257 nm and the response Lenier in the vary of 2-12μg/ml. The regression equation of the calibration format and correlation coefficient had been found to be Y = 0.0779+0.002 and 1.0 respectively. The %RSD values for each intraday and interday precision had been less than 1% the recovery of the drug from the pattern was once in precise ranged. The proposed approach used to be validated for accuracy, precision, robustness, ruggedness, LOD and LOQ whilst estimating the commercial components there was no interference of excipients and other additives. Stability study of olanzapine (Dosage Form) was carried out Accelerated study, which was perform at 40°C ± 2°C Temperature and 75% ± 5% RH (Relative Humidity) for 1st, 3rd and 6th Months. Similarly Long Term Stability study of Olanzapine (Dosage Forms) was carried out at 30°C ± 2°C Temperature and 75% ± 5% RH (Relative Humidity) for 3st, 6rd and 9th Months.

Olanzapine, UV-VIS Spectrophotometric, Validation Study and Stability Study.

"Method Development, Validation and Stability Study by UV Spectroscopic and HPLC Method for Olanzapine in Bulk and Pharmaceutical Dosage Forms", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.395-416, June-2019, Available :http://www.jetir.org/papers/JETIR1906838.pdf

"Method Development, Validation and Stability Study by UV Spectroscopic and HPLC Method for Olanzapine in Bulk and Pharmaceutical Dosage Forms", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp395-416, June-2019, Available at : http://www.jetir.org/papers/JETIR1906838.pdf