• Dr. Manoj Kumar

The emergence and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, are of great concern to the global health community. Effective treatment of a disease entails the development of new pharmaceuticals or some potential source of novel drugs. Commonly used medicinal plants of our community could be an excellent source of drugs to fight of this problem. This study is focused on exploring the antibacterial properties of Xanthium strumarium L plants leaves extracts in different solvents (methanol, ethanol and aqueous) was carried out against seven different bacterial strains, including four gram-positive (Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus and Streptococcus sp.) and three gram-negative (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhimurium) bacteria by using agar well diffusion assay (AWDA) method. Obtained results indicated that the aqueous extract gave the highest yield percentage as compared to ethanol as well as methanol extracts. The patterns of inhibition varied with the solvents extracts as well as tested bacterial strains. In the present study, samples of crude extracts displayed repressive activity against everyone treated different bacterial strains. Minimum inhibitory concentrations (MIC) a range between 12.5 to 100 mg/ml and minimum bactericidal concentration (MBC) from 12.5 to 200 mg/ml determined for the various samples of solvents extracts against the tested bacterial strains. The results showed that M. luteus among the gram-positive and E. coli among the gram-negative organisms were found highly susceptible as compared to other tested bacterial strains. An outcome of the study shows that the methanol extract had widest range of inhibitory activity as compared to the ethanol and aqueous extracts. The remarkable antibacterial activity of the leaves extracts against tested gram-positive and gram-negative bacteria suggested the possibility of employing them in drugs for the treatment of infectious diseases caused by the tested microorganisms.

Antibacterial activity; X. strumarium; Solvents extracts; Zone of Inhibition.

"EVALUATION OF ANTIBACTERIAL PROPERTIES OF XANTHIUM STRUMARIUM L. LEAVES EXTRACTS AGAINST SOME SELECTED GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.381-394, June-2019, Available :http://www.jetir.org/papers/JETIR1906E06.pdf

"EVALUATION OF ANTIBACTERIAL PROPERTIES OF XANTHIUM STRUMARIUM L. LEAVES EXTRACTS AGAINST SOME SELECTED GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp381-394, June-2019, Available at : http://www.jetir.org/papers/JETIR1906E06.pdf