• DR.Aakansha Singh
• Dr.Santosh Kumar Singh

Liver plays a central role in transforming, clearing the chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when administered within therapeutic ranges may injure this organ. The aim of our study was to investigate the relationship between liver antioxidant capacity and hepatic injury in the early phase of acute paracetamol intoxication in albino rat.A total number of 24 albino rats were included in the study and was divided into 2 groups. Group-I: Control group (n=6) and Group-II: Paracetamol treated group(n=18) in a dose of 2gm/kg b.wt. At the end of the experiment rats were sacrificed by cervical dislocation 6, 24, and 48 hours after paracetamol administration. Oxidative stress parameters were determined in blood samples spectrophotometrically. Plasma malondialdehyde was significantly increased 6 hrs after paracetamol administration in comparison with control group. After this period MDA level showed a gradual increase and reached its highest value at 48 hours after treament. Paracetamol induced a significant reduction in serum superoxide dismutase (SOD) activity at 6 hrs first. Our data showed that liver antioxidant capacity increases in first 6 hrs of paracetamol-induced liver injury. SOD activity in the serum was significantly lower in paracetamol group in comparison with control group. Similar activities were measured 24 and 48 hours after paracetamol administration. Serum activities of aminotransferases and alkaline phosphatase were significantly increased after paracetamol administration at all time intervals in comparison with control group.These effects are maintained for the next 48 hrs. On the other hand, antioxidant capacity of hepatocytes is increased within 6 hrs, at first, According to these findings, it can be estimated that antioxidant capacity should be administered as early as possible after paracetamol intoxication.

Keywords: Paracetamol, Oxidative stress,Acute hepatotoxicity, Albino rat, Antioxidant

"The Early Phase of Acute Paracetamol-Induced Liver Injury in Albino Rats.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.919-925, June 2019, Available :http://www.jetir.org/papers/JETIR1906G40.pdf

"The Early Phase of Acute Paracetamol-Induced Liver Injury in Albino Rats.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp919-925, June 2019, Available at : http://www.jetir.org/papers/JETIR1906G40.pdf