• KONGA SAHJA
• LOKESH PUDUKARAPU
• KIRANMAI BOLLAPALLI
• DR. M.G. IRFAN AHMED KHAN

Introduction: Drug-Drug Interactions(DDIs) are an avoidable cause of patient harm, may occur due to either increased effect causing toxicity or decreased effect leading to therapeutic failure and should be considered for differential diagnosis of symptoms. Objective: The main objective of this Prospective study which lasted for 6 months is to identify DDIs in Hospitalised patients and to categorize the severity and onset of interactions by the assistance of Micromedex software and to provide necessary guidance on their management for better patient care. Results: A total of 300 cases were reviewed. Of them 148 prescriptions reported 378 interactions and 152 prescriptions were without DDIs. The Mean age was 54.5(11-90) years, 69% of patients were found to be female, rest 31% were male. In total, 38% patients were diagnosed with gyneacological cancer, 37% with gastrointestinal cancer. Of all the interactions, 59.52% were classified as major, 40.21% as moderate and 0.26% as minor. Based on pharmacological mechanism, 48.13% of interactions were pharmacokinetics in origin where as 36% of interactions were pharmacodynamic and 15.87% of interactions were of unknown mechanism. Conclusion: Clinical interventions on DDIs were frequently required among the patients starting with anti-cancer therapy. Structured screening for these potentially clinically relevant DDIs by oncologists in close collaborations with clinical pharmacologists should take place before the start and during anti-cancer treatment.

Drug-Drug Interactions, Micromedex, Pharmacokinetics, Pharmcodynamics.

"Potential Drug-Drug Interactions Associated with Cancer Chemotherapy- A Prospective Observational Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.1030-1035, June 2019, Available :http://www.jetir.org/papers/JETIR1906G56.pdf

"Potential Drug-Drug Interactions Associated with Cancer Chemotherapy- A Prospective Observational Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp1030-1035, June 2019, Available at : http://www.jetir.org/papers/JETIR1906G56.pdf