• Ms Neetu Kataria
• Dr. Rajesh Kumar
• Dr. Vivekanandhan S
• Dr. Niraj Kumar
• Dr. Divya MR

Introduction: Stroke is a leading cause of long-term disability and the leading preventable cause of disability. Among ischemic stroke patients, severe hyperhomocysteinemia is due to rare genetic defects resulting in impairment of the methylation pathway like deficiencies of folate or Vitamin B12 or CBS, MTHFR thermolability. Aim: To assess the impact of genetic polymorphisms and vitamin B6, B12, Folic acid supplementations on homocysteine level. Materials and Methods: A quantitative, analytical-observational research design will be used for the study protocol. Samples will be the ischemic stroke patients who come to emergency room, Neuro OPD and Neuro ward at AIIMS, Rishikesh, Uttarakhand selected by using purposive sampling technique. Sample size will be calculated after pilot study. Tools: Subject Datasheet, NIH Stroke Scale (11items) and MRS (7items) will be used for the study. Testing for genetic polymorphisms in homocysteine, serum vitamin-B12, folic acid and serum homocysteine level will be done. Follow-up:-Total 15 months (at 1, 3, 9 & 15 months). Module development and its validation: At the end of data collection process, self-instructional discharge module will be developed and validated by experts from the items related to module. Statistical analysis: The data will be collected and analyzed by using appropriate descriptive and inferential statistics at p value considered to be significant <0.05. Discussion: This study will become beneficial for the ischemic stroke patient by decreasing level of homocysteine and risk of re-occurrence of cardiovascular related disorders.

Ischemic stroke patients, hyperhomocysteinemia, genetic polymorphisms, vitamin supplementations, self-instructional discharge module.

"“Impact of genes polymorphism and vitamin supplementations in hyperhomocysteinemia among ischemic stroke patients with a view to develop a self- instructional discharge module” A study protocol.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.336-341, June 2019, Available :http://www.jetir.org/papers/JETIR1906L51.pdf

"“Impact of genes polymorphism and vitamin supplementations in hyperhomocysteinemia among ischemic stroke patients with a view to develop a self- instructional discharge module” A study protocol.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp336-341, June 2019, Available at : http://www.jetir.org/papers/JETIR1906L51.pdf