• Nisha Shah
• Dr. Hetal K. Panchal

In recent years the rates of myocardial infarction have increased tremendously, which have increased the demand of producing an effective thrombolytic agents. The recent studies on Staphyokinase prove it to be a promising thrombolytic agent. The present work focuses on finding an effective Staphylokinase producing isolates by invitro clot lysis study. Out 28 isolates obtained, 10 isolates showed the highest invitro clot lysis activity. The optimization of Staphylokinase production was done in Satoh’s medium and the result showed that the maximum production was obtained after 48 hours at room temperature and pH 5 for most of the isolates. Most of the isolates showed maximum Staphylokinase production with glucose and beef extract carbon and nitrogen source. Hence an effective Staphyokinase producing isolated can be studied in future for obtaining maximum yield.

Thromobolytic, Staphylokinase, Invitro, Satoh’s Medium.

"Study of Invitro Clot Lysis Potential and Optimization of Staphylokinase Production", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.539-547, July-2019, Available :http://www.jetir.org/papers/JETIR1906L78.pdf

"Study of Invitro Clot Lysis Potential and Optimization of Staphylokinase Production", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp539-547, July-2019, Available at : http://www.jetir.org/papers/JETIR1906L78.pdf