• Rina Sinta Dhanu

Abstract: The purpose of this research is to determine the correlation between urine brain-derived neurotrophic factor (BDNF) and Glial cell line-derived neurotrophic factor (GDNF) on severity of overactive bladder (OAB) in women paramedics at H. Adam Malik General Hospital Medan. This research was a logistic correlation analysis with cross sectional study design on women paramedics from January 2019 till 37 samples were met using non-probability methods with consecutive sampling technique. Bivariate statistical analyzes were performed using independent T-Test if data was normally distributed or Mann Whitney U test if the data distribution was abnormal. The mean urinary bladder BDNF level in OAB group was 430.11 ± 71.26 ng / mL, higher than in non-OAB group with 230.84 ± 30.29 ng / mL. The mean level of urine GDNF in OAB group is 1318.38 ± 279.53 ng / mL higher than non- OAB group, which is 836.86 ± 119.16 ng / mL. BDNF levels <389.5 are quite high in patients with mild OAB, but overall BDNF levels increase in patients with OAB. GDNF levels tended to decrease in OAB patients with <1321.5 levels most commonly found in patients with mild OAB and overall levels of GDNF tended to decrease in patients with OAB. Based on the calculation, it was found that there was a strong correlation between BDNF and GDNF levels in severity of OAB patients with r value on BDNF and GDNF was 0.879 and 0.751, respectively.

overactive bladder¸ Brain-derived Neurotropic Factor, Glial cell line Derived Neurotropic Factor

"CORRELATION BETWEEN URINE BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF) ON SEVERITY OF OVERACTIVE BLADDER IN WOMEN PARAMEDIS AT H. ADAM MALIK GENERAL HOSPITAL MEDAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.651-656, June 2019, Available :http://www.jetir.org/papers/JETIR1906L95.pdf

"CORRELATION BETWEEN URINE BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF) ON SEVERITY OF OVERACTIVE BLADDER IN WOMEN PARAMEDIS AT H. ADAM MALIK GENERAL HOSPITAL MEDAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp651-656, June 2019, Available at : http://www.jetir.org/papers/JETIR1906L95.pdf