• SUNITHA S

Abstract: 1,3 -diphenyl-5-pyrazolone (DPP) was synthesized by reacting phnenylhyrazine and ethylbenzoylacetate. It was characterised by melting point. It was benzoylated using benzoylchloride. The benzoylated product (BDPP) was characterised by melting point. BDPP was condensed with Suphanilamide and Sulphamethoxazole to form the Schiff bases SB1 andSB2 respectively. The Schiff bases were characterised by infrared spectra, electronic, 13C NMR, 1H NMR and Mass spectral studies. The structure proposed for the Schiff bases are displayed . Kirby Bauer disc diffusion technique was used to study the antibacterial and antifungal activities. They were found to be active against the gram negative bacteria Pseudomonas eruginosa and Staphylococcus aureus and the fungi Aspergillus niger and Candida albicans. Cytotoxicity studies were carried out on SB1 Schiff base. It was found to be active against A549 human lung cancer cell lines. Hence these Schiff bases may be used as lead compounds in pharmaceutical industries.

Keywords:Pyrazolones, Schiffbases, sulpha drugs, antibacterial activity, antifungal activity, cytotoxicity.

"Schiff Bases Of 4-Benzoyl-1,3-Diphenyl-5-Pyrazolone Bearing Sulphanilamide And Sulphamethoxazole Moieties-Spectral Characterization, Anticancer And Antimicrobial Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.72-96, June 2019, Available :http://www.jetir.org/papers/JETIR1906N68.pdf

"Schiff Bases Of 4-Benzoyl-1,3-Diphenyl-5-Pyrazolone Bearing Sulphanilamide And Sulphamethoxazole Moieties-Spectral Characterization, Anticancer And Antimicrobial Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp72-96, June 2019, Available at : http://www.jetir.org/papers/JETIR1906N68.pdf